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Preimplantation Genetic Diagnosis

WHAT IS PREIMPLANTATION GENETIC DIAGNOSIS?

In vitro Fertilization (IVF) with preimplantation genetic diagnosis, is the combination of both procedures for the presence or absence of certain genetic abnormalities or alterations in the number of chromosomes in the embryos before their transfer into the uterus. Detecting chromosome problems in the embryo that is transferred, decreases the risk of miscarriage and increase the odds of having a healthy baby, free of diseases such as Down syndrome, Turner or Klinefelter's.

IN WHAT CASES IS INDICATED IVF WITH PREIMPLANTATION GENETIC DIAGNOSIS?

  • Women older than 35 years
  • Women who have completed two or more cycles of assisted reproduction without pregnancy.
  • Women who have had two or more abortions with unknown causes.
  • Women who have had a previous pregnancy with a chromosomal abnormality, especially with cycles of assisted reproduction.
  • Couples in which the man's sperm present alterations of meiosis, or a low sperm count.

WHAT IS PREIMPLANTATION GENETIC DIAGNOSIS?

This procedure consists in the biopsy or removal of a cell from the embryo in its early stages of development, usually on the third day of cultivation. The cells that are extracted are analyzed to assess the presence or absence of certain genetic or chromosomal. Once you know the genetic or chromosomal diagnosis, the embryos valued as normal will be selected for transfer or freezing. PGD improves the effectiveness of IVF preventing the transmission of diseases or genetic and chromosomal abnormalities to their future children, and to prevent certain cases of spontaneous abortions.

 

In the cycles of IVF with PGD is performed a double selection of the transferred embryos: morphological level and at the level of the chromosome. This allows you to increase the chances of pregnancy with IVF, because it minimizes the risk of transfer of embryos that are chromosomally abnormal, that tend to not get implanted or to produce miscarriages.

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